Data Driven Digital Chemistry (D3C s.r.l.) is an academic spin-off of the University of Naples Federico II, Italy. It was founded in 2025 by Professors Vincenzo Busico and Roberta Cipullo from the Laboratory of Stereoselective Polymerizations (LSP) at the Department of Chemical Sciences; Professors Francesco Calabrò and Giuseppe Izzo from the Department of Mathematics and Applications “R. Caccioppoli”; and Dr. Luca Rongo, CEO of Xplore, representing an industrial partner and minority shareholder.

The main goal of D3C is to assist chemical companies in the exploitation and customization of data digitalization, automated data mining, advanced Design of Experiments (DoE), and machine/deep learning–assisted statistical data modeling.